Pattern of Antimicrobial Resistance of Escherichia coli Isolates from Urinary Tract Infection Patients: A Three Year Retrospective Study

Article history: Received on: 07/10/2015 Revised on: 11/11/2015 Accepted on: 06/12/2015 Available online: 26/01/2016 Objectives: To study the changing pattern of antimicrobial resistance of Escherichia coli isolates from patients of urinary tract infections over last three years Materials and Methods: A retrospective, record based study carried out based on the records of Culture and sensitivity (C/S) reports of indoor patients, during past three years (2012 2014). The type of organisms most common in urine sample was noted and the drugs still effective for the particular organism were noted. Results: E. coli was the most frequent isolate throughout the three years (67.66 % of the total isolates). Analysis of the results year wise indicated that the lowest percentage of resistance was manifested against imipenem between 11.86 % (2012) and 11.36 % (2014). Resistance for nitrofurantoin decreased over the three consecutive years from 36.1 % (2012) to 18.15 % (2014). Over the successive years, resistance to ceftriaxone tends to increase from 53.39 % (2012) to 73.33 % (2014). E coli showed absolute resistance (100 %) to cotrimoxazole and tetracycline. On an average over the three years E. coli showed high amount of resistance to fluoroquinolones (75 %) and aminoglycosides (67 %).While Multi drug resistant (MDR) E. coli range between 63 % (2012) to 65 % (2014). Conclusion: The antimicrobial resistance patterns are constantly evolving and vary from region to region it has become a necessity to do constant antimicrobial sensitivity surveillance. This will help clinicians to provide safe and effective empirical therapies.